I guess this probably isn't feasible given the way I think sims sandbox scripts, but here goes anyway:
I wish that I could choose between per-script memory limits and per-sim memory limits. What I mean is, I wish I could sacrifice the ability to get essentially unlimited memory by making a ton of scripts, and instead share a much larger memory capacity among one or two scripts. It's not ideal, but it'd be better than trying to split up the logic of a big application (think game) into many scripts.